Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2

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The 7th International Symposium on Platinum and other metal coordination compounds in Cancer Chemotherapy, ISPCC '95, organized by the European Cancer Centre, was held in Amsterdam, the Netherlands, March 1-4, 1995. As with previous ISPCC meetings, the goal of ISPCC '95 was to bring together c1inicians, clinical investigators, scientists, and laboratory workers from many disciplines to promote further collaboration and cooperation in the development of new platinum and other metal coordination compounds as weil as in new ways to use 'c1assical' drugs as cisplatin and carboplatin in the treatment of cancer. Important aspects addressed by experts in the field inc1uded the synthesis and activity of new platinum compounds, the biochemistry and molecular pharrnacology as weil as the c1inical pharrnacology of this c1ass of antineoplastic agents, an overview of current c1inical studies, one special minisymposium on the mechanisms of cell kill of platinum, and one on resistance against platinum compounds. Finally, the current status of development of nonplatinum metal complexes was discussed. This volume contains the contributions of the various speakers at ISPCC '95 and provides an up-to-date and comprehensive overview of this important c1ass of anticancer agents, ranging from synthesis and molecular pharrnacology on one hand to c1inical pharrnacology and cIinical investigations on the other hand. The Organizing Corrunittee and Editors wish to express their gratitude to the contributors to this volume, to the various organizations and pharrnaceutical companies for their generous sponsoring of ISPCC '95, and to the Plenum Publishing Company for their help in producing this volume.z 9 Ap aquot; 7 Ap P 9 L pS3 STATUS WT/WT Figure 1. ... Genes that p53 induces include the DNA damage-inducible gene Gadd45, whose product binds to PCNA, a protein which is involved in DNA replication and DNA repair (15). P53 also inducesanbsp;...


Title:Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2
Author: H. M. Pinedo, J.H. Schornagel
Publisher:Springer Science & Business Media - 1996-04-30
ISBN-13:

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